Custom Enzymes and Inhibitors
Bioworld Zymolyase, 2 KU
ZymolyaseYeast lytic enzymeSpecifications:Form: Lyophilized powderSource: Arthrobacter luteusActivity: 20U/mgEssential enzyme : β-1, 3-glucan laminaripentahydrolaseOther enzyme activities contained : β-1,3-glucanase (~1.5 x106U/mg), Protease (~1.0x104U/mg), Mannanase (1.0x106U/mg), trace amounts of amylase, xylanase, phosphataseDNAse, RNAse not detectedoptimum pH: • 7.5 (@ 35°C) for cell wall lysis • 6.5 (@ 45°C) for hydrolysis of yeast glucanStable pH: 5-10Activators: SH compounds such as cysteine, β-mercacaptoethanol or DithiothreitolStability: Stable for one year at 4°CHeat stability: The lytic activity is lost on incubation at 60°C for 5 minutesUnit definition: One lytic unit is defined as catalyzing a 10% decrease in OD800 at 30°C in 30 minutes
Athens Research And Technology Inc A2 ANTIPLASMIN HU 1MG
Alpha 2 Antiplasmin, Human Plasma: 1 MG; Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl; MW 70,000; EC= 0.7; Activity: > = 5.0 IU/mg; Purity: > =95% by SDS-PAGE; This native protein purified in the Athens Research & Technology laboratory. Inhibitor, Coagulation Factor.
Athens Research And Technology Inc 100UG ANTITHROMBIN III HU
Antithrombin III, Human Plasma: 100 UG; Lyophilized from 50 mM Tris-HCl, pH 8.0, with 150 mM NaCl; MW 58,000; EC=0.7; Purity: > =95% by SDS-PAGE; This native protein purified in the Athens Research & Tech lab.
Athens Research And Technology Inc C1 ESTERASE INHIBITOR 1MG
C-1 Esterase Inhibitor, Human Plasma: 1 MG; Frozen in 20 mM potassium phosphate, pH 7.0, with 250 mM potassium chloride; MW 100,000; EC=0.4; Purity: > =95% by SDS-PAGE. This protein is prepared and purified from human plasma.
Athens Research And Technology Inc INTER ALPHA INHIBITOR PROTEIN
Inter Alpha Inhibitor Protein (IaIp), Human Plasma: 25 UG; Frozen in 1x PBS; MW 225,000 & 125,000; Purity: > =90% by SDS-PAGE. This native protein is prepared and purified from human plasma in the Athens Research & Tech lab. Molecular Biology Reagent
Selleck Chemical LLC Palbociclib (PD0332991) Isethionate 10mg 827022-33-3
Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Palbociclib (PD0332991) Isethionate 50mg 827022-33-3
Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
New England Biolabs, Inc. Shrimp Alkaline Phosphatase (rSAP) – 2500 units
Shrimp Alkaline Phosphatase (rSAP) is a heat labile alkaline phosphatase purified from a recombinant source. rSAP is identical to the native enzyme and contains no affinity tags or other modifications. rSAP nonspecifically catalyzes the dephosphorylation of 5 and 3 ends of DNA and RNA phosphomonoesters. Also, rSAP hydrolyses ribo-, as well as deoxyribonucleoside triphosphates (NTPs and dNTPs). rSAP is useful in many molecular biology applications such as the removal of phosphorylated ends of DNA and RNA for subsequent use in cloning or end-labeling of probes. In cloning, dephosphorylation prevents religation of linearized plasmid DNA. The enzyme acts on 5 protruding, 5 recessed and blunt ends. rSAP may also be used to degrade unincorporated dNTPs in PCR reactions to prepare templates for DNA sequencing or SNP analysis. rSAP is completely and irreversibly inactivated by heating at 65C for 5 minutes, thereby making removal of rSAP prior to ligation or end-labeling unnecessary.
Selleck Chemical LLC TWS119 10mM/1mL 601514-19-6
TWS119 is a GSK-3? inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3? inhibition triggers autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
New England Biolabs, Inc. Uracil Glycosylase Inhibitor (UGI) – 1000 units
The Uracil Glycosylase Inhibitor (UGI) of Bacillus subtilis bacteriophage PBS1 is a small protein (9.5 kDa) which inhibits E. coli uracil-DNA glycosylase (UDG) as well as UDG from other species. Inhibition of UDG occurs by reversible protein binding with a 1:1 UGD:UGI stoichiometry. UGI is capable of dissociating UDG-DNA complexes.
Sigma Aldrich Fine Chemicals Biosciences Paroxetine maleate salt >=98% (HPLC), solid | 64006-44-6 | MFCD01742665 | 50MG
Paroxetine maleate salt >=98% (HPLC), solid | Purity: >=98% (HPLC) | Mol Wt: 445.44 | 64006-44-6 | MFCD01742665 | 50MG
Selleck Chemical LLC SB203580 25mg 152121-47-6 RWJ 64809, PB 203580
SB203580 (RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 ?M in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 ?M. SB203580 induces mitophagy and autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Quisinostat (JNJ-26481585) 2HCl 50mg 875320-31-3
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.